Cytotoxic abietane and kaurane diterpenoids from Celastrus orbiculatus

被引:0
作者
Wei Jiang
Ti-Zhuang Shan
Jia-Jun Xu
Wen-Ju Chen
Li Miao
Meng-Ying Lv
Li Tao
Yan-Qing Liu
机构
[1] Yangzhou University,Marine Science and Technology Institute
[2] Yangzhou University,College of Medicine
[3] Wenzhou Medical College,School of Pharmacy
[4] Harbin University of Commerce,Research Center of Life and Environment Science
来源
Journal of Natural Medicines | 2019年 / 73卷
关键词
Abietane-type diterpenoid; Kaurane-type diterpenoid; Cytotoxic activity;
D O I
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中图分类号
学科分类号
摘要
Celastrus orbiculatus is a medicinal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining antitumor substances, the chemical constituents of the stems of C. orbiculatus were investigated. Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with six other known abietane-type diterpenoids (2–7) and five known kaurane-type diterpenoids (8–12) were isolated and identified from the EtOAc extract of C. orbiculatus. Their structures were elucidated on the basis of extensive spectroscopic methods, including UV, IR, HR-ESI–MS, ECD, and NMR experiments, and by comparison with literature data. Compound 1 is a new C19-norabietane diterpenoid with 19 carbons. All compounds except for 10 and 11 were isolated from C. orbiculatus for the first time. The NMR data of 9 were reported for the first time. Compounds 1, 7 and 11 showed cytotoxicities against SGC-7901 with IC50 values of 63.2, 80.9 and 56.7 μM, respectively.
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页码:841 / 846
页数:5
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