Review article: BK virus in systemic lupus erythematosus

被引：0
作者：
Nirupama Gupta
Robert M. Lawrence
Cuong Nguyen
Renee F. Modica
机构：
[1] College of Medicine,Division of Nephrology, Department of Pediatrics
[2] University of Florida,Division of Immunology, Rheumatology and Infectious Diseases, Department of Pediatrics
[3] College of Medicine,Department of Infectious Diseases and Pathology
[4] University of Florida,undefined
[5] College of Veterinary Medicine,undefined
[6] University of Florida,undefined
来源：
Pediatric Rheumatology | / 13卷
关键词：
BK virus; SLE; Immunosuppression;
D O I：
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学科分类号：
摘要：
BK virus (BKV) is a human polyomavirus with a seroprevalence of 60–80 % in the general population. In renal transplant patients, it is known to cause renal failure, ureteric stenosis and hemorrhagic cystitis. In bone marrow transplant patients, it is evident that BKV can also cause hemorrhagic cystitis along with BK virus nephropathy (BKVN) in the native kidneys, with subsequent renal failure. However, little is known about BVKN in non-transplanted immune-compromised patients, such as systemic lupus erythematosus (SLE) who may have underlying nephritis and have a compromised immune system due to therapy and/or systemic illness. Thus, this article will focus on the clinical aspects of BKV and its association in patients with SLE.
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