Effects of cyclosporin a on proliferation of cultured rat mesangial cells

被引：0
作者：
Sun Jumping
Wang Yunqin
机构：
[1] Tongji Medical University,Department of Pediatrics, Tongji Hospital
来源：
Current Medical Science | 1997年 / 17卷 / 2期
关键词：
cyclosporin A; mesangial cells; tumor necrosis factor-α;
D O I：
10.1007/BF02888248
中图分类号：
学科分类号：
摘要：
The proliferation of mesangial cells on cyclosporin (CsA) test medium was studied by MTT assay and TNF-α in cultured supernatant was examined by using ELISA. The results showed that cyclosporin A significantly inhibited the proliferation of mesangial cells at the concentration between 0. 25 – 15 μg/ml (IC50 1 μg/ml). This action appeared to be dose-dependent. Release of TNF-α from mesangial cells stimulated by LPS was also dose-dependently suppressed. It is suggested that cyclosporin A play an important role in antiprohferation mechanism of mesangial cellsin vitro.
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页码：115 / 117
页数：2
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