Fibroblast growth factor 23 and bone mineralisation

被引：0
作者：
Yu-Chen Guo
Quan Yuan
机构：
[1] State Key Laboratory of Oral Diseases,
[2] West China Hospital of Stomatology,undefined
[3] Sichuan University,undefined
[4] Chengdu,undefined
[5] China,undefined
来源：
International Journal of Oral Science | 2015年 / 7卷
关键词：
bone mineralisation; chronic kidney disease; fibroblast growth factor 23;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Fibroblast growth factor 23 (FGF23) is a hormone that is mainly secreted by osteocytes and osteoblasts in bone. The critical role of FGF23 in mineral ion homeostasis was first identified in human genetic and acquired rachitic diseases and has been further characterised in animal models. Recent studies have revealed that the levels of FGF23 increase significantly at the very early stages of chronic kidney disease (CKD) and may play a critical role in mineral ion disorders and bone metabolism in these patients. Our recent publications have also shown that FGF23 and its cofactor, Klotho, may play an independent role in directly regulating bone mineralisation instead of producing a systematic effect. In this review, we will discuss the new role of FGF23 in bone mineralisation and the pathophysiology of CKD-related bone disorders.
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页码：8 / 13
页数：5
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