Elevated second trimester serum homocysteine levels in women with gestational diabetes mellitus

被引：44

作者：

Guven M.A. ^{[1
]}

Kilinc M. ^{[2
]}

Batukan C. ^{[3
]}

Ekerbicer H.C. ^{[4
]}

Aksu T. ^{[5
]}

机构：

[1] School of Medicine, Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, 46100 Kahramanmaras, Yenisehir Mh., Cumhuriyet Blv.

[2] School of Medicine, Department of Biochemistry, Kahramanmaras Sutcu Imam University, Kahramanmaras

[3] School of Medicine, Department of Obstetrics and Gynecology, Erciyes University, Kayseri

[4] School of Medicine, Department of Public Health, Kahramanmaras Sutcu Imam University, Kahramanmaras

[5] Kahramanmaras Women's Health Government Hospital, Kahramanmaras

来源：

Archives of Gynecology and Obstetrics | 2006年 / 274卷 / 6期

关键词：

Folate; Gestational diabetes mellitus; Glucose intolerance; Homocysteine; Pregnancy; Vitamin B12;

D O I：

10.1007/s00404-006-0191-6

中图分类号：

学科分类号：

摘要：

Objective: Our aim was to investigate the association between total serum homocysteine, vitamin B12 and folate levels in pregnant women with gestational diabetes mellitus (GDM), glucose intolerance and compare them with those of glucose tolerant pregnant women. Materials and methods: Serum homocysteine, vitamin B12 and serum folate levels were prospectively measured in a total of 223 pregnant women who were grouped according to their status of glucose tolerance as gestational diabetes (abnormal 1-h and 3-h glucose tolerance test; n = 30), glucose intolerant (abnormal 1-h, but normal 3-h glucose tolerance test; n = 46) or normal controls (normal 1-h glucose test; n = 147). Results: Mean serum homocysteine concentration of women in gestational diabetes, glucose intolerants and normal controls at 24-28 weeks of gestation was 9.0 ± 3.1, 8.1 ± 2.5 and 7.4 ± 1.6 μmol/l, respectively. The only statistically difference in homocysteine levels was observed between women with gestational diabetes and normal controls (P < 0.01). However, no difference was observed for vitamin B12 and folate levels. Conclusion: Second trimester serum homocysteine concentrations are higher among women with GDM, as compared to normal controls. © Springer-Verlag 2006.

引用

页码：333 / 337

页数：4

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