Structural determinants of protein folding

被引：0
作者：
Tse Siang Kang
R. Manjunatha Kini
机构：
[1] The Scripps Research Institute,Department of Pharmacy
[2] National University of Singapore,Department of Biological Sciences
[3] National University of Singapore,undefined
来源：
Cellular and Molecular Life Sciences | 2009年 / 66卷
关键词：
Protein folding; Folding models; Folding propensity; Structural determinants; Posttranslational modifications; Secondary structures;
D O I：
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学科分类号：
摘要：
The last several decades have seen an explosion of knowledge in the field of structural biology. With critical advances in spectroscopic techniques in examining structures of biomacromolecules, in maturation of molecular biology techniques, as well as vast improvements in computation prowess, protein structures are now being elucidated at an unprecedented rate. In spite of all the recent advances, the protein folding puzzle remains as one of the fundamental biochemical challenges. A facet to this empiric problem is the structural determinants of protein folding. What are the driving forces that pivot a polypeptide chain to a specific conformation amongst the vast conformation space? In this review, we shall discuss some of the structural determinants to protein folding that have been identified in the recent decades.
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页码：2341 / 2361
页数：20
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