Vitamin D3 Supplementation Effects on Spermatogram and Oxidative Stress Biomarkers in Asthenozoospermia Infertile Men: a Randomized, Triple-Blind, Placebo-Controlled Clinical Trial

被引：0
作者：
Leila Maghsoumi-Norouzabad
Ahmad Zare Javid
Anahita Mansoori
Mohammadreza Dadfar
Amirarsalan Serajian
机构：
[1] Ahvaz Jundishapur University of Medical Sciences,Department of Nutrition, School of Allied Medical Sciences
[2] Ahvaz Jundishapur University of Medical Sciences,Nutrition and Metabolic Diseases Research Center
[3] Imam Khomeini Hospital,Department of Urology, School of Medicine
[4] Ahvaz Jundishapur University of Medical Sciences,undefined
[5] Health Education Group,undefined
[6] Jahad Daneshgahi,undefined
来源：
Reproductive Sciences | 2022年 / 29卷
关键词：
Vitamin D3; Oxidative stress; Asthenozoospermia; Sperm quality;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The objective is to evaluate the effects of vitamin D3 (VD3) on sperm parameters and seminal and serum oxidative stress (OS) biomarkers in asthenozoospermia infertile men. This randomized, triple-masking, placebo-controlled clinical trial conducted on 86 asthenozoospermia infertile men with serum 25 hydroxy vitamin D3 (25-OH-D3) < 30 ng/ml in the infertility clinic of Ahvaz Jahad Daneshgahi, Iran. Patients were randomly allocated to groups A and B, who received daily 4000 IU vitamin D3 (VD3) and matching placebo respectively for 3 months. Demographic data, dietary intake, physical activity, sun exposure, anthropometric indices, serum and seminal levels of MDA (Malondialdehyde), 8-hydroxy-2- Dioxy Guanosine (8-OHDG), total antioxidant capacity (TAC) and calcium, sperm DNA fragmentation index (DFI), serum 25-OH-D3, parathyroid hormone (PTH), phosphorus, and sperm parameters were assessed. VD3 supplementation had no significant effects on body weight, body mass index (BMI), waist circumference (WC), body fat (BF), 8-OHDG, DFI, semen volume, sperm count, and normal sperm morphology, but increased post-intervention mean and mean change of serum 25-OH-D3 (P < 0.001, P < 0.001), PTH (P < 0.001, P < 0.001) and phosphorus (P = 0.009, P = 0.049) and seminal calcium (P = 0.035, P = 0.038) and serum calcium (P = 0.008, P = 0.009), seminal TAC (P < 0.001, P < 0.001), and serum TAC (P = 0.007, P = 005), total sperm motility (P < 0.001, P < 0.001) and progressive sperm motility (P < 0.001, P < 0.001) and decreased seminal MDA (P = 0.017, P = 0.004) and serum MDA (P = 006, P = 0.005) significantly compared to the baseline and placebo group respectively. VD3 supplementation may modulate OS and affect sperm motility in men with asthenozoospermia and serum 25-OH-D3 < 30 ng/ml. Iran Clinical Trials Registry, ID: IRCT20151128025274N4, registered on 28 March 2018, URL of trial registry record: https://www.irct.ir/trial/29983
引用
收藏
页码：823 / 835
页数：12
相关论文
共 205 条
  • [1] Kazemijaliseh H(2015)The prevalence and causes of primary infertility in Iran: a population-based study Global J Health Sci 7 226-232
  • [2] Ramezani Tehrani F(2014)Psychological impact of infertility among infertile women Adv Nurs Midwifery 23 1-10
  • [3] Behboudi-Gandevani S(2015)Trends of male factor infertility, an important cause of infertility: a review of literature J Hum Reprod Sci 8 191-196
  • [4] Hosseinpanah F(2017)Major regulatory mechanisms involved in sperm motility Asian J Androl 19 5-14
  • [5] Khalili D(2019)From past to present: the link between reactive oxygen species in sperm and male infertility Antioxidants (Basel, Switzerland) 8 616-635
  • [6] Azizi F(2015)Contemporary evidence on the physiological role of reactive oxygen species in human sperm function J Assist Reprod Genet 32 509-520
  • [7] Hasanpoor Azghdy SB(2014)Review of clinical trials on effects of oral antioxidants on basic semen and other parameters in idiopathic oligoasthenoteratozoospermia Biomed Res Int 2014 1-11
  • [8] Simbar M(2020)An update on the management of male infertility Obstet Gynaecol 22 267-74
  • [9] Vedadhir A(2014)Male infertility testing: reactive oxygen species and antioxidant capacity Fertil Steril 102 1518-1527
  • [10] Hossein Rashid B(2021)Dietary antioxidants in the treatment of male infertility: counteracting oxidative stress Biology 10 241-280
12345678910