Design, synthesis and fungicidal activity of novel strobilurin-1,2,4-triazole derivatives containing furan or thiophene rings

A series of strobilurin-1,2,4-triazole derivatives containing a furan or thiophen ring was designed and synthesized. The structures of the compounds were characterized by 1H NMR, 13C NMR and HRMS spectra. The bioassays indicated that the fungicidal activities of compounds 10b(EC50=14.82 mg/L) and 10c(EC50=18.72 mg/L) against Cercospora arachidicola Hori in vitro were much higher than that of Azoxystrobin as control(EC50=40.54 mg/L) and the fungicidal activities of compounds 10u(EC50=8.66 mg/L) and 10n(EC50=9.89 mg/L) against Rhizotonia cerealis in vitro were higher than that of the same control(EC50=10.86 mg/L). Compounds 10b, 10c, 10n and 10k could be considered as the leading compounds for further investigation.