Failure of repetition suppression and memory encoding in aging and Alzheimer’s disease

被引：0
作者：
Maija Pihlajamäki
Kelly O’Keefe
Jackie O’Brien
Deborah Blacker
Reisa A. Sperling
机构：
[1] University of Eastern Finland,Unit of Neurology, Institute of Clinical Medicine
[2] Kuopio University Hospital,Department of Neurology
[3] Harvard Medical School,Memory Disorders Unit, Department of Neurology, Brigham and Women’s Hospital
[4] Massachusetts General Hospital,Department of Psychiatry
[5] Massachusetts General Hospital,Athinoula A. Martinos Center for Biomedical Imaging
来源：
Brain Imaging and Behavior | 2011年 / 5卷
关键词：
Aging; Alzheimer’s disease; Functional magnetic resonance imaging; Medial temporal lobe; Memory; Repetition suppression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The suppression of neural activity in the medial temporal lobe (MTL) has been suggested as a marker of successful recognition of familiarity in healthy subjects, but to be impaired in patients with Alzheimer’s disease (AD). In this study, we investigated whether the ability to suppress MTL activity during repeated exposure to face-name pairs was related to the ability to successfully encode novel associations in 90 individuals ranging from healthy young and older subjects to mildly impaired elderly and AD patients. Activity in the anterior MTL during Repeated stimuli was inversely related to performance in post-scan associative recognition for the Novel face-name pairs. In a subset (n = 60) of subjects undergoing more detailed neuropsychological testing, greater MTL Repeated activity was correlated with worse word-list delayed recall performance. Failure of response suppression to familiar information may be a sensitive marker of MTL dysfunction and memory impairment in aging and prodromal AD.
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页码：36 / 44
页数：8
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