An Interleukin-10 Gene Promoter Polymorphism (−592A/C) Associated with Type 2 Diabetes: A North Indian Study

被引：0
作者：
Madhukar Saxena
C. G. Agrawal
Hemant Kumar Bid
Monisha Banerjee
机构：
[1] University of Lucknow,Molecular and Human Genetics Laboratory, Department of Zoology
[2] Chhatrapati Shahuji Maharaj Medical University,Department of Medicine
[3] Research Institute at Nationwide Children’s Hospital,Peter Houghton Lab, Center for Childhood Cancer
来源：
Biochemical Genetics | 2012年 / 50卷
关键词：
SNP; Type 2 diabetes mellitus; Interleukin-10; North Indian population; ELISA; PCR–RFLP;
D O I：
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摘要：
In this first report on the association of an IL-10 promoter polymorphism with type 2 diabetes mellitus in a North Indian population, the −592A/C SNP (rs1800872) was genotyped by PCR–RFLP and the IL-10 level measured using ELISA. Although no significant difference was observed in the genotypic frequencies (P = 0.657), diabetes patients carried a significantly higher number of A alleles at the −592 position, 25.6% (P < 0.001, odds ratio 0.887, 95% CI 0.670–1.184). Significant correlations were detected in postprandial glucose levels of CC-genotype patients and controls (P = 0.025), age and waist–hip ratio of CA patients and controls (P ≤ 0.001), and fasting glucose (P = 0.045) and low-density lipoprotein (P = 0.049) in all patients and controls. The serum IL-10 level was significantly higher in patients than in controls (P = 0.033). The polymorphism was significantly associated with disease incidence and its biochemical manifestations.
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页码：549 / 559
页数：10
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