Sex differences in the association between cardiovascular diseases and dementia subtypes: a prospective analysis of 464,616 UK Biobank participants

被引：0
作者：
Caiyun Dong
Chunmiao Zhou
Chunying Fu
Wenting Hao
Akihiko Ozaki
Nipun Shrestha
Salim S. Virani
Shiva Raj Mishra
Dongshan Zhu
机构：
[1] Cheeloo College of Medicine,Centre for Health Management and Policy Research, School of Public Health
[2] Shandong University,NHC Key Lab of Health Economics and Policy Research
[3] Shandong University,Department of Breast Surgery
[4] Jyoban Hospital of Tokiwa Foundation,Department of Gastrointestinal Tract Surgery
[5] Fukushima Medical University,Department of Primary Care and Mental Health
[6] University of Liverpool,Melbourne School of Population and Global Health
[7] Michael E. DeBakey VA Medical Center and Baylor College of Medicine,Department of Epidemiology, School of Public Health
[8] Academy for Data Sciences and Global Health,undefined
[9] The University of Melbourne,undefined
[10] Cheeloo College of Medicine,undefined
[11] Shandong University,undefined
来源：
Biology of Sex Differences | / 13卷
关键词：
Sex difference; Coronary heart diseases; Stroke; Heart failure; Alzheimer’s disease; Vascular dementia; Cohort study;
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摘要：
Whether the incidence and timing of dementia is affected by an interaction of sex with cardiovascular diseases (CVD) events is unclear.We evaluated the sex-specific difference in dementia risk associated with CVDs, including its unique interaction with social, behavioral, genetic, and medical factors.Women with coronary heart disease and heart failure were 1.6 and 1.3 times more likely to develop Alzheimer’s disease than men with the same condition.Men with heart failure had 1.4 times higher risk of having vascular dementia than women.Socioeconomic, lifestyle, genetic, and medical factors moderated the sex-specific association between CVD and dementia.
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