Prevalence of Acanthosis Nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome

被引：16

作者：

Dassanayake A.S. ^{[1
]}

Kasturiratne A. ^{[1
]}

Niriella M.A. ^{[1
]}

Kalubovila U. ^{[1
]}

Rajindrajith S. ^{[1
]}

De Silva A.P. ^{[1
]}

Kato N. ^{[2
]}

Wickremasinghe A.R. ^{[1
]}

De Silva H.J. ^{[1
]}

机构：

[1] Faculty of Medicine, University of Keleniya, Ragama

[2] International Medical Centre of Japan, Tokyo

来源：

BMC Research Notes | / 4卷 / 1期

关键词：

Insulin Resistance; Metabolic Syndrome; Positive Predictive Value; Negative Predictive Value; Clinical Marker;

D O I：

10.1186/1756-0500-4-25

中图分类号：

学科分类号：

摘要：

Background. Insulin resistance (IR) plays a major role in the pathogenesis of metabolic syndrome. Acanthosis nigricans (AN) is an easily detectable skin condition that is strongly associated with IR. The aims of this study were, firstly, to investigate the prevalence of AN among adults in an urban Sri Lankan community and secondly, to describe its utility to detect metabolic syndrome. Findings. In a community based investigation, 35-64 year adults who were selected using stratified random sampling, underwent interview, clinical examination, liver ultrasound scanning, and biochemical and serological tests. Metabolic syndrome was diagnosed on revised ATP III criteria for Asian populations. AN was identified by the presence of dark, thick, velvety skin in the neck. 2957 subjects were included in this analysis. The prevalence of AN, metabolic syndrome and type 2 diabetes mellitus were 17.4%, 34.8% and 19.6%, respectively. There was a strong association between AN and metabolic syndrome. The sensitivity, specificity, positive predictive value and negative predictive value of AN to detect metabolic syndrome were 28.2%, 89.0%, 45.9% and 79.0% for males, and 29.2%, 88.4%, 65.6% and 62.3% for females, respectively. Conclusions. AN was common in our study population, and although it did not have a high enough sensitivity to be utilized as a screening test for metabolic syndrome, the presence of AN strongly predicts metabolic syndrome. © 2011 de Silva et al; licensee BioMed Central Ltd.

引用

共 16 条

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