On Statistical Relationship between ADRA2A Expression and the Risk of Breast Cancer Relapse

被引：0

作者：

M. Yu. Shkurnikov

V. V. Galatenko

A. E. Lebedev

V. E. Podol’skii

E. A. Tonevitskii

D. V. Mal’tseva

机构：

[1] Russian Academy of Medical Sciences,Research Institute of General Pathology and Pathophysiology

[2] M. V. Lomonosov Moscow State University,undefined

[3] Scientific and Technical Center BioKlinikum,undefined

来源：

Bulletin of Experimental Biology and Medicine | 2014年 / 157卷

关键词：

gene expression; breast cancer; risk of relapse; α-2A adrenergic receptor;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The search for novel parameters to predict the risk of relapse in breast cancer was conducted. Significant correlation between the risk of relapse and α-2A adrenergic receptor (ADRA2A) expression was revealed using public microarray datasets. This relationship was confirmed by validation on independent microarray dataset. It was found that when assessing the risk of BC relapse, the accuracy of prediction based solely on the expression of ADRA2A gene is close to that made using OncotypeDX and MammaPrint test systems. In this case, addition of only one or two supplemental prognostic markers (for instance, expression of SQLE gene or SQLE and DSCC1genes) to ADRA2A ensures the accuracy of prediction not inferior to reliability of these test systems.

引用

页码：454 / 458

页数：4

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