Facile synthesis and biological evaluation of heterocyclic compounds containing Diazepam

被引:0
作者
M. A. Berghot
机构
[1] Mansoura University,Department of Chemistry, Faculty of Science
来源
Archives of Pharmacal Research | 2001年 / 24卷
关键词
Diazepam; Biodynamic heterocyclic systems; Triazoles; Thiadiazoles; Oxadiazoles;
D O I
暂无
中图分类号
学科分类号
摘要
Diazepamoxadiazoles4,5,6,12,14 and22 were prepared with the binary form system. Diazepamthiadiazoles15,20 and Diazepamtriazoles7,8,9,17,18,19 and21 were also shapely synthesized. Some of these compounds were screened to test their antibacterial activity againstE. coli andB. subtilis compounds 15 and 20 show potent activity against these bacteria.
引用
收藏
页码:263 / 269
页数:6
相关论文
共 57 条
[1]  
Aboulwafa O. M.(1992)Synthesis, and antimicrobial activity of Benzo[b]thienyl-1,3,4-oxadiazole, 1,2,4-triazole and thidiazole derivatives Arch. Die Pharm. 325 123-127
[2]  
Berto A. G.(1993)Synthesis, Spectral and biological studies of some heterocyclic systems containing anthraquinone Pharmazie 47 340-343
[3]  
Berghot M. A.(1992)Heterocyclic groups annulated to 1,4-benzodiazepine systems Arch. Die Pharm. 325 285-289
[4]  
Hanna M. A.(1991)Synthesis, Anti-microbial activities of novel triazolo-quinolines Arch. Die Pharm. 324 249-253
[5]  
Girges M. M.(1961)The anticonvulsive action of acetazolamide and its derivatives Acta physiol. Acad. Sci. Hung. 19 95-102
[6]  
Berghot M. A.(1978)Synthesis and biological action of 6-phenyl-pyrrolo[1,2-a][1,4]benzodiazepines J. Med. Chem. 21 263-266
[7]  
El-Sayed O. A.(1977)Radioprotective effect of thiadiazole derivatives UUSR Khim. Farm. Zh. 11 48-53
[8]  
Farghaly A. M.(1977)Reactions of chlorodiazepoxide and diazepam Chem. Pharm. Bull. 25 3247-3251
[9]  
Habib N. S.(1996)-oxide with dimethyl acetylene dicarboxylate Indian J. Chem. 35B 339-344
[10]  
Khalil M.A.(1971)Synthesis and antimicrobial activity of 1,3,4-oxadiazolyl-1,8-naphtho pyridines J. Pharmacol. 21 497-500