Esophageal Dysmotility, Gastro-esophageal Reflux Disease, and Lung Transplantation: What Is the Evidence?

被引：13

作者：

Wood R.K. ^{[1
]}

机构：

[1] Division of Gastroenterology, Duke University Medical Center, DUMC 3662, Durham, 27710, NC

来源：

Current Gastroenterology Reports | 2015年 / 17卷 / 12期

关键词：

Bronchiolitis obliterans syndrome; Esophageal dysmotility; Fundoplication; Gastro-esophageal reflux disease; Lung transplantation; Obliterative bronchiolitis;

D O I：

10.1007/s11894-015-0474-9

中图分类号：

学科分类号：

摘要：

Lung transplantation is an effective and life-prolonging therapy for patients with advanced lung disease (ALD). However, long-term patient survival following lung transplantation is primarily limited by development of an inflammatory and fibrotic process involving the lung allograft known as bronchiolitis obliterans syndrome (BOS). Although the precise cause of BOS remains uncertain and is likely multifactorial, chronic aspiration of gastro-duodenal contents is one possible contributing factor. Multiple small, cross-sectional studies performed over the past two decades have reported a high prevalence of gastro-esophageal reflux disease (GERD) and esophageal dysmotility in the ALD population and several investigations suggest the prevalence may increase following lung transplantation. More recent studies evaluating the direct effect of gastro-duodenal contents on airways have demonstrated a possible biologic link between GERD and BOS. Despite the recent advances in our understanding of BOS, further investigations are needed to establish GERD as a causative factor in its development. This review will discuss the existing literature that has identified an association of GERD with ALD and post-transplant populations, with a focus on recent advances in the field. © 2015, Springer Science+Business Media New York.

引用

页数：8

共 60 条

[1] Yusen R.D., Et al., The registry of the international society for heart and lung transplantation: thirty-first adult lung and heart-lung transplant report--2014
[2] focus theme: retransplantation, J Heart Lung Transplant, 33, 10, pp. 1009-1024, (2014)
[3] Lodhi S.A., Lamb K.E., Meier-Kriesche H.U., Solid organ allograft survival improvement in the United States: the long-term does not mirror the dramatic short-term success, Am J Transplant, 11, 6, pp. 1226-1235, (2011)
[4] Belperio J.A., Et al., Chronic lung allograft rejection: mechanisms and therapy, Proc Am Thorac Soc, 6, 1, pp. 108-121, (2009)
[5] Robertson A.G., Et al., Lung transplantation, gastroesophageal reflux, and fundoplication, Ann Thorac Surg, 89, 2, pp. 653-660, (2010)
[6] Sato M., Et al., Restrictive allograft syndrome (RAS): a novel form of chronic lung allograft dysfunction, J Heart Lung Transplant, 30, 7, pp. 735-742, (2011)
[7] Gulack B.C., Et al., Reflux and allograft dysfunction: is there a connection?, Thorac Surg Clin, 25, 1, pp. 97-105, (2015)
[8] Estenne M., Et al., Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria, J Heart Lung Transplant, 21, 3, pp. 297-310, (2002)
[9] Hartwig M.G., Et al., Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation, J Thorac Cardiovasc Surg, 131, 1, pp. 209-217, (2006)
[10] Cantu E., Et al., J. Maxwell chamberlain memorial paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease, Ann Thorac Surg, 78, 4, pp. 1142-1151, (2004)

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