Osteoradionecrosis of the Jaws: Clinico-Therapeutic Management: A Literature Review and Update

被引：64

作者：

Nadella K.R. ^{[1
]}

Kodali R.M. ^{[1
]}

Guttikonda L.K. ^{[1
]}

Jonnalagadda A. ^{[1
]}

机构：

[1] Department of Oral and Maxillofacial Surgery, Drs. Sudha & Nageswara Rao, Siddhartha Institute of Dental Sciences, Chinnaoutpalli, Gannavaram, Vijayawada

来源：

Journal of Maxillofacial and Oral Surgery | 2015年 / 14卷 / 4期

关键词：

Bisphosphonate osteonecrosis; Etiology; Osteoradionecrosis; Pathophysiology; Risk factors; Treatment options;

D O I：

10.1007/s12663-015-0762-9

中图分类号：

学科分类号：

摘要：

Osteoradionecrosis is one of the most serious oral complications of head and neck cancer treatment. It is a severe delayed radiation-induced injury, characterized by bone tissue necrosis and failure to heal for at least 3 months. In most cases osteoradionecrosis gradually progresses, becoming more extensive and painful that leads to infection and pathological fracture. The present paper provides a literature review and update on the risk factors underlying osteoradionecrosis, its clinical and diagnostic particulars, prevention and most widely accepted treatment options including the latest treatment modalities. Lastly, a new early management protocol is proposed based on the current clinical criteria relating to osteonecrosis secondary to treatment with bisphosphonates, together with the adoption of new therapies supported by increased levels of evidence. © 2015, The Association of Oral and Maxillofacial Surgeons of India.

引用

页码：891 / 901

页数：10

共 32 条

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