Parent-reported outcomes for treatment of acute otitis media with cefdinir or amoxicillin/clavulanate oral suspensions

被引：8
作者：
Cifaldi M.A. [1 ,3 ]
Paris M.M. [2 ]
Devcich K.J. [2 ]
Bukofzer S. [2 ]
机构：
[1] Hlth. Econ. and Outcomes Research, Abbott Laboratories, Abbott Park, IL
[2] Clinical Research, Abbott Laboratories, Abbott Park, IL
[3] Ctr. Pharm. Appraisals/Outcomes Res., Abbott Laboratories, Bldg. AP9A, Abbott Park, IL 60064-6124
来源：
Pediatric Drugs | 2004年 / 6卷 / 6期
关键词：
Azithromycin; Acute Otitis Medium; Antibiotic Selection; Oral Suspension; Cefprozil;
D O I：
10.2165/00148581-200406060-00006
中图分类号：
学科分类号：
摘要：
Objective: To compare parent-reported outcomes (satisfaction, tolerability, compliance, and work/daycare missed) for children (aged 6 months to 6 years) receiving either cefdinir or amoxicillin/clavulanate for acute otitis media. Method: In a phase IV, investigator-blinded, parallel-group, randomized, multicenter study, parents or legal guardians were asked to complete the Otitis Parent Questionnaire (OPQ) 12-14 days after the first dose of cefdinir or amoxicillin/clavulanate oral suspensions. Responses in each of the outcome domains were analyzed using non-parametric statistical analysis. Results: Of 367 parents/guardians who completed the questionnaire, better ease of use (p = 0.009) and taste (p < 0.0001) were associated with cefdinir versus amoxicillin/clavulanate treatment, and children were significantly more likely to experience vomiting with amoxicillin/clavulanate (16% vs 8%; p = 0.016). Parents also reported that their children were much more likely to take all of their medication if receiving cefdinir (68% vs 53% for amoxicillin/clavulanate; p = 0.005). There were no statistically significant differences between groups in work/daycare missed. Conclusion: Based on parents' assessment using the OPQ, cefdinir was easier to administer and tasted better than amoxicillin/ clavulanate. Children who received cefdinir also experienced less vomiting and had greater compliance than children who received amoxicillin/clavulanate.
引用
收藏
页码：387 / 393
页数：6
相关论文
共 33 条
  • [1] Bauchner H., Klein J.O., Parental issues in selection of antimicrobial agents for infants and children, Clin Pediatr, 36, 4, pp. 201-205, (1997)
  • [2] Iwai N., Drug compliance of children and infants with oral antibiotics for paediatric use, Acta Paediatr Jpn, 39, 1, pp. 132-142, (1997)
  • [3] Ramgoolam A., Steele R., Formulations of antibiotics for children in primary care: Effects on compliance and efficacy, Paediatr Drugs, 4, 5, pp. 323-333, (2002)
  • [4] Dagan R., Shvartzman P., Liss Z., Variation in acceptance of common oral antibiotic suspensions, Pediatr Infect Dis J, 13, 8, pp. 686-690, (1994)
  • [5] Steele R.W., Thomas M.P., Begue R.E., Compliance issues related to the selection of antibiotic suspensions for children, Pediatr Infect Dis J, 20, 1, pp. 1-5, (2001)
  • [6] Matsui D., Barron A., Rieder M.J., Assessment of the palatability of antistaphylococcal antibiotics in paediatric volunteers, Ann Pharmacother, 30, 6, pp. 586-588, (1996)
  • [7] Steele R.W., Blumer J.L., Kalish G.H., Patient, physician, and nurse satisfaction with antibiotics, Clin Pediatr, 41, 5, pp. 285-299, (2002)
  • [8] Garau J., Why do we need to eradicate pathogens in respiratory tract infections?, Int J Infect Dis, 7, SUPPL. 1, (2003)
  • [9] Song J.H., Introduction: The goals of antimicrobial therapy, Int J Infect Dis, 7, SUPPL. 1, (2003)
  • [10] Klein J.O., Otitis media, Clin Infect Dis, 19, pp. 823-833, (1994)
1234