Theoretical conformational analysis of tetrapeptide Ac-Cys-Pro-Ala-Cys-NHMe with disulfide linkage

被引：0
作者：
Jun Yoshimoto
Akira Nishinaga
Masahito Oka
Toshio Hayashi
机构：
[1] Nagoya University,Graduate School of Human Informatics
[2] Osaka Institute of Technology,Department of Applied Chemistry
[3] Osaka Prefecture University,Research Institute of Advanced Science and Technology
来源：
Polymer Bulletin | 1997年 / 38卷
关键词：
Conformational Energy; Disulfide Linkage; Conformational Preference; Cyclic Tetrapeptides; Theoretical Conformational Analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Theoretical conformational analysis was carried out for the acyclic and cyclic tetrapeptides Ac-Cys-Pro-Ala-Cys-NHMe using ECEPP and optimization procedure for investigating the conformational preference of peptides having disulfide linkage. Calculated results indicate that cyclic Ac-Cys-Pro-Ala-Cys-NHMe forms compactly fold conformations with type III–III double bend at the Pro-Ala-Ala portion, and also show fairly good agreement with experimental results of the NMR spectroscopy for the tetrapeptides having Cys-Pro-Ala-Cys sequence.
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页码：227 / 234
页数：7
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