Solid Lipid Nanoparticles for the Nucleic Acid Encapsulation

被引：0

作者：

O. V. Zaborova

A. D. Voinova

B. D. Shmykov

V. G. Sergeyev

机构：

[1] Department of Chemistry, Moscow State University, Moscow

来源：

Reviews and Advances in Chemistry | 2021年 / 11卷 / 3-4期

关键词：

colloidal drug carriers; DNA encapsulation; solid lipid nanoparticles;

D O I：

10.1134/S2079978021030055

中图分类号：

学科分类号：

摘要：

Abstract: We report the formation of lipid nanoparticles (LNPs) capable to encapsulate up to 70% of added DNA molecules and stable within 2.5 weeks. The novelty of the suggested approach is in the components used for nanoparticle formation. The standard components of LNPs are amine, phospholipid, cholesterol and lipid conjugated with poly(ethyleneglycol) (PEGylated). We suggested to combine two components – cholesterol and PEGylated lipid. Thus, studied LNPs contained three components: PEGylated cholesterol, oleylamine and three types of phosphocholine differed in alkyl chain length. © Pleiades Publishing, Ltd. 2021.

引用

页码：178 / 188

页数：10