Studies on the Inclusion Complex of Diloxanide Furoate-\boldbeta-Cyclodextrin

Cyclodextrins are a group of cyclic oligosaccharides which have shown to improve pharmaceutical properties of drugs, such as solubility and stability, by forming inclusion complexes. Diloxanide furoate has direct amoebicide action on the intestinal lumen and little solubility in water. In this work, solubility, NMR, fluorescence techniques, and kinetic methods were used to determine the equilibrium constant for the formation of the β-cyclodextrin–diloxanide furoate complex, K1:1. It is shown that the kinetic approach is the best method for such a determination.