Roles of BCCIP in chromosome stability and cytokinesis

被引：0
作者：
X Meng
J Fan
Z Shen
机构：
[1] University of New Mexico School of Medicine,Department of Molecular Genetics and Microbiology
[2] The Cancer Institute of New Jersey,Department of Radiation Oncology
[3] Robert Wood Johnson Medical School,undefined
来源：
Oncogene | 2007年 / 26卷
关键词：
cytokinesis; chromosome instability; BRCA2; BCCIP; polyploidy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The BRCA2 gene is involved in recombinational DNA repair and cytokinesis. BRCA2 defects are associated with chromosomal abnormalities, which is a hallmark of genomic instability that contributes to tumorigenesis. Here, we show that downregulation of a BRCA2 interacting protein (BCCIP) in HT1080 cells leads to chromosomal polyploidization, centrosome amplification and abnormal mitotic spindle formation. The BCCIP knockdown cells can enter mitosis and retain spindle checkpoint, but fail to complete cytokinesis. Our data suggest an essential role of BCCIP in the maintenance of genomic integrity.
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页码：6253 / 6260
页数：7
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