Functional Neuroimaging of Social and Nonsocial Cognitive Control in Autism

被引：0
作者：
Antoinette Sabatino
Alison Rittenberg
Noah J. Sasson
Lauren Turner-Brown
James W. Bodfish
Gabriel S. Dichter
机构：
[1] University of North Carolina at Chapel Hill,Department of Psychology
[2] University of North Carolina at Chapel Hill,Carolina Institute for Developmental Disabilities
[3] The University of Texas at Dallas,School of Behavioral and Brain Sciences
[4] Vanderbilt University,Departments of Hearing and Speech Sciences and Psychiatry
[5] University of North Carolina at Chapel Hill,Department of Psychiatry
[6] Duke-UNC Brain Imaging and Analysis Center,undefined
来源：
Journal of Autism and Developmental Disorders | 2013年 / 43卷
关键词：
Autism; Functional magnetic resonance imaging; cognitive control; Repetitive behaviors; Frontostriatal;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study investigated cognitive control of social and nonsocial information in autism using functional magnetic resonance imaging. Individuals with autism spectrum disorders (ASDs) and a neurotypical control group completed an oddball target detection task where target stimuli were either faces or nonsocial objects previously shown to be related to circumscribed interests in autism. The ASD group demonstrated relatively increased activation to social targets in right insular cortex and in left superior frontal gyrus and relatively decreased activation to nonsocial targets related to circumscribed interests in multiple frontostriatal brain regions. Findings suggest that frontostriatal recruitment during cognitive control in ASD is contingent on stimulus type, with increased activation for social stimuli and decreased activation for nonsocial stimuli related to circumscribed interests.
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页码：2903 / 2913
页数：10
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  • [1] Agam Y(2010)Reduced cognitive control of response inhibition by the anterior cingulate cortex in autism spectrum disorders NeuroImage 52 336-347
  • [2] Joseph RM(2001)The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians Journal of Autism and Developmental Disorders 31 5-17
  • [3] Barton JJ(2003)General multilevel linear modeling for group analysis in FMRI NeuroImage 20 1052-1063
  • [4] Manoach DS(2001)Conflict monitoring and cognitive control Psychological Review 108 624-652
  • [5] Baron-Cohen S(2007)Relative glucose metabolic rate higher in white matter in patients with schizophrenia American Journal of Psychiatry 164 1072-1081
  • [6] Wheelwright S(2001)Sensitivity of prefrontal cortex to changes in target probability: A functional MRI study Human Brain Mapping 13 26-33
  • [7] Skinner R(2006)An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest NeuroImage 31 968-980
  • [8] Martin J(2012)Functional magnetic resonance imaging of autism spectrum disorders Dialogues Clinical Neuroscience 14 319-351
  • [9] Clubley E(2007)Social stimuli interfere with cognitive control in autism NeuroImage 35 1219-1230
  • [10] Beckmann CF(2009)Autism is characterized by dorsal anterior cingulate hyperactivation during social target detection Social Cognitive and Affective Neuroscience 4 215-226
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