High expression of CD9 and Epidermal Growth Factor Receptor promotes the development of tongue cancer

被引：0
作者：
P. C. Suhasini
Vadisha Bhat
Shilpa S Shetty
Praveen Kumar Shetty
P. G. Roopashree
N. Suchetha Kumari
机构：
[1] NITTE (Deemed to be University),Department of Biochemistry, KS Hegde Medical Academy
[2] NITTE (Deemed to be University),Department of ENT, KS Hegde Medical Academy
[3] NITTE (Deemed to be University),Cellomics, Lipdomics and Molecular Genetics division, Central Research Laboratory, KS Hegde Medical Academy
来源：
Medical Oncology | / 41卷
关键词：
CD9; Hypoxia; EFGR; Akt; Tongue cancer;
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摘要：
Tongue cancer is distinguished by aggressive behavior, a high risk of recurrence, lymph, and distant metastases. Hypoxia-Induced Factor 1 α functions as a CD9 transcription factor. CD9 is a transmembrane protein that may be found on the cell membrane. It can modulate the expression of the Epidermal Growth Factor Receptor (EGFR) pathway. ELISA was used to measure serum CD9, p-EGFR, and p-Akt levels in 70 tongue cancer patients and 35 healthy controls. RT-PCR was used to analyze the gene expression of the related genes. The gene as well as protein expression of CD9, EGFR/p-EGFR, and Akt/p-Akt was significantly higher in case subjects when compared with the controls. The expression of CD9 was higher in case subjects who were smokers/alcoholics when to control subjects who were smokers/alcoholics. Overexpression of CD9 due to hypoxic conditions leads to the activation of EGFR-signaling pathway resulting in cancer progression, resistance to chemotherapy. Hence, CD9 could be a potential target to suppress cancer progression.
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