Novel role of PKR in inflammasome activation and HMGB1 release

被引：0

作者：

Ben Lu

Takahisa Nakamura

Karen Inouye

Jianhua Li

Yiting Tang

Peter Lundbäck

Sergio I. Valdes-Ferrer

Peder S. Olofsson

Thomas Kalb

Jesse Roth

Yongrui Zou

Helena Erlandsson-Harris

Huan Yang

Jenny P.-Y. Ting

Haichao Wang

Ulf Andersson

Daniel J. Antoine

Sangeeta S. Chavan

Gökhan S. Hotamisligil

Kevin J. Tracey

机构：

[1] Laboratory of Biomedical Science,Department of Genetics & Complex Diseases

[2] The Feinstein Institute for Medical Research,Department of Medicine

[3] 350 Community Drive,Department of Microbiology and Immunology

[4] Manhasset,Department of Emergency Medicine

[5] New York 11030,Department of Molecular and Clinical Pharmacology

[6] USA,undefined

[7] The Elmezzi Graduate School of Molecular Medicine,undefined

[8] North Shore-LIJ Health system,undefined

[9] 350 Community Drive,undefined

[10] Manhasset,undefined

[11] New York 11030,undefined

[12] USA,undefined

[13] Harvard School of Public Health,undefined

[14] Center for Autoimmunity and Musculoskeletal Diseases,undefined

[15] Feinstein Institute for Medical Research,undefined

[16] Manhasset,undefined

[17] New York,undefined

[18] New York 11030,undefined

[19] USA,undefined

[20] Karolinska Institute,undefined

[21] Karolinska University Hospital,undefined

[22] Stockholm S-17176,undefined

[23] Sweden,undefined

[24] Women’s and Children’s Health,undefined

[25] Karolinska Institute,undefined

[26] Karolinska University Hospital,undefined

[27] Stockholm S-17176,undefined

[28] Sweden,undefined

[29] University of North Carolina at Chapel Hill,undefined

[30] North Shore University Hospital,undefined

[31] MRC Centre for Drug Safety Science,undefined

[32] University of Liverpool,undefined

[33] Liverpool L69 3GE,undefined

[34] UK,undefined

来源：

Nature | 2012年 / 488卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Double-stranded RNA-dependent protein kinase (PKR) is shown to be a key regulator of the inflammasome; PKR is central for caspase-1 activation and the release of interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1) in response to a diverse range of stimuli.

引用

页码：670 / 674

页数：4

共 50 条

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