Listening for hoof beats in heart beats

被引:0
作者
Jeffrey Robbins
Gerald W Dorn
机构
[1] Division of Molecular Cardiovascular Biology Children's Hospital Research Foundation,
[2] Division of Cardiology University of Cincinnati,undefined
来源
Nature Medicine | 2000年 / 6卷
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学科分类号
摘要
Disruption of the Sp1-related transcription factor HF-1b leads to alterations in the cardiac conduction system that result in ventricular arrhythmias and sudden death. What does this tell us about how ventricular cardiomyocytes differentiate into the specialized cells that form the heart's conductance system?
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页码:968 / 970
页数:2
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  • [1] Geisterfer-Lowrance AA(1990)A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation Cell 62 999-1006
  • [2] Wang Z(1999)Functional effects of mutations in KvLQT1 that cause long QT syndrome J. Cardiovasc. Electrophysiol. 10 817-826
  • [3] Ackerman MJ(1998)The long QT syndrome: ion channel diseases of the heart Mayo Clin. Proc. 73 250-269
  • [4] Schott JJ(1998)Congenital heart disease caused by mutations in the transcription factor NKX2-5 Science 281 108-111
  • [5] Basson CT(1997)Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome Nature Genet. 15 30-35
  • [6] Supp DM(1996)Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility Dev. Biol. 176 284-299
  • [7] Witte DP(2000)In vivo induction of cardiac Purkinje fiber differentiation by co-expression of preproendothelin-1 and endothelin converting enzyme-1 Development 127 3523-3532
  • [8] Branford WW(1999)Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system Circ. Res. 84 146-152
  • [9] Smith EP(1998)Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice J. Clin. Invest. 101 51-61
  • [10] Potter SS(undefined)undefined undefined undefined undefined-undefined