Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

被引：0

作者：

Louise J Young

Nicholas S Wilson

Petra Schnorrer

Anna Proietto

Toine ten Broeke

Yohei Matsuki

Adele M Mount

Gabrielle T Belz

Meredith O'Keeffe

Mari Ohmura-Hoshino

Satoshi Ishido

Willem Stoorvogel

William R Heath

Ken Shortman

Jose A Villadangos

机构：

[1] The Walter and Eliza Hall Institute of Medical Research,Department of Medical Biology

[2] University of Melbourne,Department of Biochemistry and Cell Biology

[3] University of Melbourne,undefined

[4] The Cooperative Research Centre for Vaccine Technology,undefined

[5] Faculty of Veterinary Medicine,undefined

[6] Utrecht University,undefined

[7] Laboratory for Infectious Immunity,undefined

[8] RIKEN Research Center for Allergy and Immunology,undefined

[9] Yokohama,undefined

[10] 1-7-22,undefined

[11] Suehiro-cho,undefined

[12] Tsurumi-ku,undefined

[13] Present address: Department of Molecular Oncology,undefined

[14] Genentech,undefined

[15] California 94080,undefined

[16] USA (N.S.W.); Division of Molecular Immunology,undefined

[17] German Cancer Research Centre,undefined

[18] D-69120 Heidelberg,undefined

[19] Germany (P.S.); Bavarian-Nordic,undefined

[20] Martinsried 82152,undefined

[21] Germany (M.O.); Department of Microbiology and Immunology,undefined

[22] University of Melbourne,undefined

[23] Parkville,undefined

[24] Victoria 3050,undefined

[25] Australia (W.R.H.).,undefined

来源：

Nature Immunology | 2008年 / 9卷

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学科分类号：

摘要：

The antigen-presenting abilities of plasmacytoid dendritic cells (DCs) are not well characterized. Villadangos and colleagues show that unlike conventional DCs, plasmacytoid DCs continue to synthesize and degrade MHC class II molecules, and thereby present endogenous viral antigen, after activation.

引用

页码：1244 / 1252

页数：8

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