Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

被引:0
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作者
Louise J Young
Nicholas S Wilson
Petra Schnorrer
Anna Proietto
Toine ten Broeke
Yohei Matsuki
Adele M Mount
Gabrielle T Belz
Meredith O'Keeffe
Mari Ohmura-Hoshino
Satoshi Ishido
Willem Stoorvogel
William R Heath
Ken Shortman
Jose A Villadangos
机构
[1] The Walter and Eliza Hall Institute of Medical Research,Department of Medical Biology
[2] University of Melbourne,Department of Biochemistry and Cell Biology
[3] University of Melbourne,undefined
[4] The Cooperative Research Centre for Vaccine Technology,undefined
[5] Faculty of Veterinary Medicine,undefined
[6] Utrecht University,undefined
[7] Laboratory for Infectious Immunity,undefined
[8] RIKEN Research Center for Allergy and Immunology,undefined
[9] Yokohama,undefined
[10] 1-7-22,undefined
[11] Suehiro-cho,undefined
[12] Tsurumi-ku,undefined
[13] Present address: Department of Molecular Oncology,undefined
[14] Genentech,undefined
[15] California 94080,undefined
[16] USA (N.S.W.); Division of Molecular Immunology,undefined
[17] German Cancer Research Centre,undefined
[18] D-69120 Heidelberg,undefined
[19] Germany (P.S.); Bavarian-Nordic,undefined
[20] Martinsried 82152,undefined
[21] Germany (M.O.); Department of Microbiology and Immunology,undefined
[22] University of Melbourne,undefined
[23] Parkville,undefined
[24] Victoria 3050,undefined
[25] Australia (W.R.H.).,undefined
来源
Nature Immunology | 2008年 / 9卷
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摘要
The antigen-presenting abilities of plasmacytoid dendritic cells (DCs) are not well characterized. Villadangos and colleagues show that unlike conventional DCs, plasmacytoid DCs continue to synthesize and degrade MHC class II molecules, and thereby present endogenous viral antigen, after activation.
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页码:1244 / 1252
页数:8
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