Effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17

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作者
Francisco Tsz Tsun Lai
Min Fan
Caige Huang
Celine Sze Ling Chui
Eric Yuk Fai Wan
Xue Li
Carlos King Ho Wong
Ching-Lung Cheung
Ian Chi Kei Wong
Esther Wai Yin Chan
机构
[1] The University of Hong Kong,Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine
[2] Hong Kong Science Park,Laboratory of Data Discovery for Health (D24H)
[3] University of Hong Kong,School of Nursing, Li Ka Shing Faculty of Medicine
[4] University of Hong Kong,School of Public Health, Li Ka Shing Faculty of Medicine
[5] University of Hong Kong,Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine
[6] University of Hong Kong,Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine
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Nature Communications | / 14卷
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摘要
Extended intervals between the first and second doses of mRNA Covid-19 vaccines may reduce the risk of myocarditis in children and adolescents. However, vaccine effectiveness after this extension remains unclear. To examine this potential variable effectiveness, we conducted a population-based nested case-control study of children and adolescents aged 5–17 years who had received two doses of BNT162b2 in Hong Kong. From January 1 to August 15, 2022, 5396 Covid-19 cases and 202 Covid-19 related hospitalizations were identified and matched with 21,577 and 808 controls, respectively. For vaccine recipients with extended intervals [≥28 days, adjusted odds ratio 0.718, 95% Confidence Interval: 0.619, 0.833] there was a 29.2%-reduced risk of Covid-19 infection compared to those with regular intervals (21–27 days). If the threshold was set at eight weeks, the risk reduction was estimated at 43.5% (aOR 0.565, 95% CI: 0.456, 0.700). In conclusion, longer dosing intervals for children and adolescents should be considered.
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