A novel electrochemical 99Mo/99mTc generator

被引：0
作者：
Rubel Chakravarty
Meera Venkatesh
Ashutosh Dash
机构：
[1] Bhabha Atomic Research Centre,Radiopharmaceuticals Division
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2011年 / 290卷
关键词：
Electrode potential; Mo/; Tc generator; (n, γ); Mo; Radionuclidic purity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A novel electrochemical process to avail clinical grade 99mTc from (n,γ)99Mo has been demonstrated. The electrochemical parameters were optimized to maximize the 99mTc yield with minimal 99Mo contamination. 99Mo/99mTc generators containing up to 29.6 GBq (800 mCi) 99Mo were developed and their performance were extensively evaluated for 10 days without changing the operating conditions. Very high radioactive concentration of 99mTcO4− of acceptable quality, commensurate with hospital radiopharmacy requirements could be availed from the system with >90% yield. The compatibility of the product for the formulation of 99mTc labeled radiopharmaceuticals such as 99mTc-DMSA and 99mTc-EC was found to be satisfactory in terms of high labeling yields. The proposed route represents an important step for enhancing the scope of accessing clinical grade 99mTc from low specific activity (n, γ)99Mo.
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