Preliminary experience offering oocyte donation to human immunodeficiency virus-1 serodiscordant couples

被引：3

作者：

Joseph E. Peña

Melvin H. Thornton

Mark V. Sauer

机构：

[1] Department of Obstetrics, C.-P. Med. Ctr. Columbia Univ., College of Physicians and Surgeons, New York, NY 10032

来源：

Archives of Gynecology and Obstetrics | 2003年 / 268卷 / 3期

关键词：

HIV; In vitro fertilization; Intracytoplasmic sperm injection; Oocyte donation; Serodiscordant;

D O I：

10.1007/s00404-002-0458-5

中图分类号：

学科分类号：

摘要：

Case report: Our preliminary experience on the use of donor oocytes in human immunodeficiency virus-1 (HIV-1) serodiscordant couples who have previously failed conventional in vitro fertilization (IVF) therapy is presented. Five HIV-1 serodiscordant couples in which the male is infected and the female is seronegative underwent IVF with intracytoplasmic sperm injection (ICSI) utilizing donor oocytes with day 3 embryo transfer and cryopreservation. Six oocyte donation cycles in the five couples yielded 16.8±9.5 (mean±SD) (range 11-34) oocytes; 3.8±0.4 (range 3-4) transferred embryos; and 1.8±2.2 (range 0-5) cryopreserved embryos per attempt. The fertilization rate from ICSI was 0.60±0.16 (range 0.40-0.88). Three of five couples conceived; two from one attempt (one singleton pregnancy and one twin pregnancy); and another after a failed fresh cycle using cryopreserved embryos. All female recipients tested remained seronegative 3 and 6 months post-embryo transfer. All babies (n=4) were seronegative at birth and 3 months postpartum. Conclusion: Oocyte donation may be considered as an alternative for childbearing in HIV serodiscordant couples in whom conventional IVF has failed due to factors inherent to the female partner.

引用

页码：202 / 205

页数：3

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