The potential mechanism of Bupleurum against anxiety was predicted by network pharmacology study and molecular docking

被引:0
作者
Han-Biao Wu
Yu-Gang Xiao
Ji-Sheng Chen
Zhi-Kun Qiu
机构
[1] The First Affiliated Hospital of Guangdong Pharmaceutical University,Key Specialty of Clinical Pharmacy
来源
Metabolic Brain Disease | 2022年 / 37卷
关键词
Network pharmacology study; Molecular docking; bupleurum; Anxiety; Signaling pathway;
D O I
暂无
中图分类号
学科分类号
摘要
Bupleurum chinense DC. (Chaihu) is a traditional Chinese medicine (TCM) used in the treatment of anxiety. But the anxiolytic mechanisms of bupleurum are still unclear. Therefore, this unknown is predicted by network pharmacology study with molecular docking in the present study. The components of bupleurum were obtained from the databases. Genes associated with components and disease were also provided by databases. Overlapping genes between components and disease were analyzed. The network of medicine-components-targets-disease was constructed, visualized, and analyzed. Protein-protein interaction (PPI), gene ontology (GO), pathway enrichment (KEGG) and molecular docking were conducted to predict the potential mechanisms of bupleurum on anxiety. A total of 9 bioactive components derived from bupleurum with 80 target genes were involved in anxiety. Neurotransmitter receptor activity, G protein-coupled amine receptor activity, regulation of blood circulation, neuroactive ligand-receptor interaction, calcium signaling pathway and salivary secretion may play significant roles in the anxiolytic of bupleurum. Molecular docking implicated that ACHE and MAOA showed high affinity for stigmasterol. Based on network pharmacology study with molecular docking, multi-component-multi-target-multi-pathway action mode of bupleurum on anxiety was elaborated. Stigmasterol might be the core bioactive component, while ACHE and MAOA might be the core target genes in the pharmacological profile of bupleurum on anxiety.
引用
收藏
页码:1609 / 1639
页数:30
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