The impact of germline BRCA pathogenic variants in locally advanced, triple negative breast cancer treated with platinum-based neoadjuvant chemotherapy

被引:0
作者
Raz Mutai
Iryna Kuchuk
Alexandra Goldshtein
Rinat Yerushalmi
Ofer Rotem
Adi Maisel Lotan
Tali Bdolah-Abram
Alberto Gabizon
Hadar Goldvaser
机构
[1] Davidoff Cancer Center,The Oncology Institute
[2] Rabin Medical Center,Department of Military Medicine and “Tzameret”, Faculty of Medicine
[3] Faculty of Medicine Tel-Aviv University,Plastic Surgery Department, Shaare Zedek Medical Center, Faculty of Medicine
[4] Meir Medical Center,Faculty of Medicine
[5] Hebrew University of Jerusalem,The Helmsley Cancer Center, Shaare Zedek Medical Center, Faculty of Medicine
[6] Medical Corps,undefined
[7] Israel Defense Forces,undefined
[8] Hebrew University,undefined
[9] Hebrew University,undefined
[10] Hebrew University,undefined
来源
Breast Cancer Research and Treatment | 2024年 / 205卷
关键词
Breast cancer; Neoadjuvant chemotherapy; BRCA mutation; Triple negative;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:241 / 248
页数:7
相关论文
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  • [1] Karim AM(2023)Triple-negative breast cancer: epidemiology, molecular mechanisms, and modern vaccine-based treatment strategies Biochem Pharmacol 212 115545-173
  • [2] Eun Kwon J(2016)Comparison of clinicopathological features and prognosis in triple-negative and non-triple negative breast cancer J Cancer 7 167-1432
  • [3] Ali T(2021)Profile of pathogenic mutations and evaluation of germline genetic testing criteria in consecutive breast cancer patients treated at a north indian tertiary care center Ann Surg Oncol 29 1423-2405
  • [4] Jang J(2018)Association between BRCA status and triple-negative breast cancer: a meta-analysis Front Pharmacol 21 909-516
  • [5] Ullah I(2021)Adjuvant olaparib for patients with BRCA1- or BRCA2-mutated breast cancer N Engl J Med 384 2394-637
  • [6] Lee YG(2016)Oncotype-DX recurrence score distribution in breast cancer patients with BRCA1/2 mutations Breast Cancer Res Treat 157 511-1508
  • [7] Park DW(2022)molecular characterization by the 21-gene breast cancer (BC) recurrence score (RS) test of BRCA1/2 mutation carriers (MBRCA1/2) versus the general BC patient (PT) population Ann Oncol 33 152p-748
  • [8] Qiu J(2018)Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: The TNT trial Nat Med 24 628-21
  • [9] Xue X(2018)Platinum-based neoadjuvant chemotherapy in triple-negative breast cancer: a systematic review and meta-analysis Ann Oncol 29 1497-146
  • [10] Hu C(2020)Association of germline variant status with therapy response in high-risk early-stage breast cancer: a secondary analysis of the GeparOcto randomized clinical trial JAMA Oncol 6 744-172