Polymorphisms in the leptin receptor gene, body composition and fat distribution in overweight and obese women

被引：0
作者：
M Wauters
I Mertens
M Chagnon
T Rankinen
RV Considine
YC Chagnon
LF Van Gaal
C Bouchard
机构：
[1] Metabolism and Clinical Nutrition,Department of Endocrinology
[2] University Hospital Antwerp,Division of Endocrinology and Metabolism
[3] Human Genomics Laboratory,Division of Kinesiology, Department of Social and Preventive Medicine
[4] Pennington Biomedical Research Center,undefined
[5] Louisiana State University,undefined
[6] Indiana University School of Medicine,undefined
[7] Physical Activity Sciences Laboratory,undefined
[8] Laval University,undefined
[9] Ste-Foy,undefined
来源：
International Journal of Obesity | 2001年 / 25卷
关键词：
leptin receptor; obesity; body composition; abdominal fat distribution; leptin; genetic polymorphisms;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
OBJECTIVE: Leptin is an adipocyte-secreted hormone involved in body weight regulation, acting through the leptin receptor, localised centrally in the hypothalamus as well as peripherally, amongst others on adipose tissue. The aim of this study was to evaluate whether polymorphisms in the leptin receptor (LEPR) gene were related to obesity and body fat distribution phenotypes, such as waist and hip circumferences and the amount of visceral and subcutaneous fat.
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页码：714 / 720
页数：6
相关论文
共 290 条
[1]  
Zhang Y(1994)Positional cloning of the mouse Nature 372 425-431
[2]  
Proenca R(1995) gene and its human homologue Nature Med 1 950-953
[3]  
Maffei M(1996)Overexpression of the obese ( New Engl J Med 334 292-295
[4]  
Barone M(1996)) gene in adipose tissue of human obese subjects Nature 379 632-635
[5]  
Leopold L(1996)Serum immunoreactive-leptin concentrations in normal-weight and obese humans Cell 84 491-495
[6]  
Friedman JM(1996)Abnormal splicing of the leptin receptor in diabetic mice Science 271 994-996
[7]  
Lönnqvist F(1996)Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in Proc Natl Acad Sci USA 93 6231-6235
[8]  
Arner P(1999)/ Int J Obes Relat Metab Disord 23 83-89
[9]  
Nordfors L(1995) mice Cell 83 1263-1271
[10]  
Schalling M(1996)Phenotypes of mouse Diabetes 19 992-994
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