Cytochrome c oxidase: exciting progress and remaining mysteries

被引：0
作者：
Peter Brzezinski
Robert B. Gennis
机构：
[1] Stockholm University,Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences
[2] University of Illinois,Department of Biochemistry
来源：
Journal of Bioenergetics and Biomembranes | 2008年 / 40卷
关键词：
Oxidase; Cytochrome; Proton; Redox; Energy coupling; Pump; Heme; Copper;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cytochrome c oxidase generates a proton motive force by two separate mechanisms. The first mechanism is similar to that postulated by Peter Mitchell, and is based on electrons and protons used to generate water coming from opposite sides of the membrane. The second mechanism was not initially anticipated, but is now firmly established as a proton pump. A brief review of the current state of our understanding of the proton pump of cytochrome oxidase is presented. We have come a long way since the initial observation of the pump by Mårten Wikström in 1977, but a number of essential questions remain to be answered.
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页码：521 / 531
页数：10
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