MUC1 gene overexpressed in breast cancer: structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ERα) in regulation of the MUC1 gene expression

被引:0
作者
Joseph Z Zaretsky
Itay Barnea
Yael Aylon
Marat Gorivodsky
Daniel H Wreschner
Iafa Keydar
机构
[1] Tel Aviv University,Department of Cell Research and Immunology, Faculty of Life Sciences
[2] Weizmann Institute of Science,Department of Molecular and Cell Biology
[3] NICHD,Laboratory of Mammalian Genes and Development, Section on Transgene Regulation
[4] NIH,undefined
来源
Molecular Cancer | / 5卷
关键词
Estrogen Receptor; MCF7 Cell; T47D Cell; MUC1 Expression; MUC1 Gene;
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  • [1] Gendler SJ(1995)Epithelial mucin genes Annu Rev Physiol 57 607-634
  • [2] Spicer AP(1990)Expression of genes coding for pS2, c-erbB2, estrogen receptor and the H23 breast tumor-associated antigen. A comparative analysis in breast cancer FEBS Lett 265 46-50
  • [3] Zaretsky JZ(1995)Is episialin/MUC1 involved in breast cancer progression? Cancer Lett 90 27-33
  • [4] Weiss M(1990)Human epithelial tumor antigen cDNA sequences. Differential splicing may generate multiple protein forms Eur J Biochem 189 463-473
  • [5] Tsarfaty I(1998)Expression of MUC-1 glycoprotein in plasma cells, follicular dendritic cells, myofibroblasts and perineurial cells: immunohistochemical analysis using three monoclonal antibodies Pathol Int 48 776-785
  • [6] Hareuveni M(1998)Expression of MUC1 mucin on activated human T cells: implications for a role of MUC1 in normal immune regulation Cancer Res 58 4079-4081
  • [7] Wreschner DH(2005)A novel protein derived from the MUC1 gene by alternative splicing and frameshifting J Biol Chem 280 10655-10663
  • [8] Keydar I(1999)The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein Cancer Res 59 1552-1561
  • [9] Hilkens J(2001)Human MUC1 mucin: a potent glandular morphogen J Pathol 194 373-383
  • [10] Vos HL(2002)Expression of MUC1 splice variants in benign and malignant ovarian tumours Int J Cancer 100 166-171