Mechanisms of osteocyte mechanotransduction

被引：7
作者：
Bakker A.D. [1 ]
Klein-Nulend J. [1 ]
机构：
[1] Department of Oral Cell Biology, Academic Centre for Dentistry, Amsterdam-University of Amsterdam, 1081 LA Amsterdam
来源：
Clinical Reviews in Bone and Mineral Metabolism | 2010年 / 8卷 / 4期
关键词：
Adaptation; Fluid flow; Fluid shear stress; Mechanotransduction; Osteocytes; Strain;
D O I：
10.1007/s12018-010-9079-x
中图分类号：
学科分类号：
摘要：
Healthy bones combine a proper resistance against fracture with a minimum use of material. This property is likely brought about by osteocytes in response to mechanical cues, but it is still unknown how whole bone loads are translated into a signal that can be sensed by the osteocytes. The goal of this chapter is to critically analyze our current knowledge on how bone transduction takes place from the level of mechanical loads placed upon the bone as an organ to activation of a cell. © Springer Science+Business Media, LLC 2010.
引用
收藏
页码：163 / 169
页数：6
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