The (R)-omeprazole hydroxylation index reflects CYP2C19 activity in healthy Japanese volunteers

被引:0
作者
Satoshi Yamada
Hideo Shiohira
Norio Yasui-Furukori
Tomonori Tateishi
Yumiko Akamine
Tsukasa Uno
机构
[1] Faculty of Medicine,Department of Hospital Pharmacy
[2] University of the Ryukyus,Department of Neuropsychiatry
[3] Hirosaki University School of Medicine,undefined
[4] Pharmaceuticals and Medical Devices Agency,undefined
来源
European Journal of Clinical Pharmacology | 2013年 / 69卷
关键词
CYP2C19; (; )-omeprazole; (; )-5-hydroxyomeprazole; (; )-omeprazole; (; )-5-hydroxyomeprazole; Hydroxylation index;
D O I
暂无
中图分类号
学科分类号
摘要
引用
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页码:1423 / 1428
页数:5
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[1]  
De Morais SM(1994)Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese Mol Pharmacol 46 594-598
[2]  
Wilkinson GR(2008)Stereoselective disposition of proton pump inhibitors Clin Drug Investig 28 263-279
[3]  
Blaisdell J(2001)Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole Clin Pharmacokinet 40 411-426
[4]  
Meyer UA(2006)The effect of CYP2C19 polymorphisms on H. pylori eradication rate in dual and triple first-line PPI therapies: a meta- analysis Am J Gastroenterol 101 1467-1475
[5]  
Nakamura K(2007)Pharmacogenomics-based tailored versus standard therapeutic regimen for eradication of H. pylori Clin Pharmacol Ther 81 521-528
[6]  
Goldstein JA(2001)Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin Clin Pharmacol Ther 69 158-168
[7]  
Andersson T(2004)CYP2C19 polymorphism is a major predictor of treatment failure in white patients by use of lansoprazole-based quadruple therapy for eradication of Helicobacter pylori Clin Pharmacol Ther 76 201-209
[8]  
Weidolf L(2003)A proton-pump inhibitor expedition: The case histories of omeprazole and esomeprazole Nat Rev Drug Discov 2 132-139
[9]  
Andersson T(2010)A randomized controlled trial: Efficacy and safety of azathromycin, ofloxacin, bismutu and omeprazole compared with amoxicillin, clarithromycin, bismuth, and omeprazole as second-line therapy in patients with Helicobacter pylori infection Helicobacter 15 154-159
[10]  
Hassan-Alin M(2010)Drug-drug interaction profiles of proton pump inhibitors Clin Pharmacokinet 1 509-533