Estrogen deficiency causes central leptin insensitivity and increased hypothalamic neuropeptide Y

被引:0
|
作者
DA Ainslie
MJ Morris
G Wittert
H Turnbull
J Proietto
AW Thorburn
机构
[1] University of Melbourne,Department of Medicine
[2] University of Melbourne,Department of Pharmacology
[3] University of Adelaide,Department of Medicine
[4] Royal Adelaide Hospital,undefined
来源
International Journal of Obesity | 2001年 / 25卷
关键词
estrogen; leptin receptor; neuropeptide Y; motor activity; energy intake; energy metabolism;
D O I
暂无
中图分类号
学科分类号
摘要
OBJECTIVE: Altered fat distribution is a consequence of menopause, but the mechanisms responsible are unknown. Estrogen insufficiency in humans can be modeled using ovariectomized rats. We have shown that increased adiposity in these rats is due to reduced physical activity and transient hyperphagia, and can be reversed with 17β-estradiol treatment. The aims of this study were to examine whether this altered energy balance is associated with circulating leptin insufficiency, central leptin insensitivity, decreased hypothalamic leptin receptor (Ob-Rb) expression, and/or increased hypothalamic neuropeptide Y (NPY).
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页码:1680 / 1688
页数:8
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