Radiolabeling of 1-[N′,N′-bis(2-chloroethyl)-4-aminophenyl]-N- methyl-fullereno-C60-[1,9-c]pyrrolidine with 125I

被引：0

作者：

Ran T. ^{[1
,2
]}

Liu R. ^{[1
,2
]}

Yin J. ^{[1
,2
]}

Zhu J. ^{[3
]}

Li W. ^{[1
]}

Li Q. ^{[1
]}

机构：

[1] Shanghai Institute of Applied Physics, Chinese Academy of Sciences

[2] Graduate School of Chinese Academy of Sciences

[3] School of Pharmacy, Fudan University

来源：

Journal of Radioanalytical and Nuclear Chemistry | 2006年 / 268卷 / 3期

基金：

中国国家自然科学基金;

关键词：

Fullerene; High Pressure Liquid Chromatography; Pyrrolidine; Isotope Exchange; Radiochemical Purity;

D O I：

10.1007/s10967-006-0213-7

中图分类号：

学科分类号：

摘要：

A procedure for labeling of a fullerene derivative 1-[N′,N′- bis(2-chloroethyl)-4-aminophenyl]-N-methyl-fullereno-C60-[1,9-c] pyrrolidine (C60-C13H18N2Cl 2) with 125I is reported. The compound was first iodinated with a large excess of iodine monochloride and then radiolabeled by isotopic exchange with Na125I in a toluene-water two-phase system. The dependence of the radiolabehng yield on the reaction temperature and exchange time was examined. The radiolabeling yield of the compound was as high as 94% after heating for 2 hours at 130°C. © 2006 Akadémiai Kiadó.

引用

页码：599 / 603

页数：4

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