Radiolabeling of 1-[N′,N′-bis(2-chloroethyl)-4-aminophenyl]-N- methyl-fullereno-C60-[1,9-c]pyrrolidine with 125I

被引：0
|
作者：
Ran T. [1 ,2 ]
Liu R. [1 ,2 ]
Yin J. [1 ,2 ]
Zhu J. [3 ]
Li W. [1 ]
Li Q. [1 ]
机构：
[1] Shanghai Institute of Applied Physics, Chinese Academy of Sciences
[2] Graduate School of Chinese Academy of Sciences
[3] School of Pharmacy, Fudan University
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2006年 / 268卷 / 3期
基金：
中国国家自然科学基金;
关键词：
Fullerene; High Pressure Liquid Chromatography; Pyrrolidine; Isotope Exchange; Radiochemical Purity;
D O I：
10.1007/s10967-006-0213-7
中图分类号：
学科分类号：
摘要：
A procedure for labeling of a fullerene derivative 1-[N′,N′- bis(2-chloroethyl)-4-aminophenyl]-N-methyl-fullereno-C60-[1,9-c] pyrrolidine (C60-C13H18N2Cl 2) with 125I is reported. The compound was first iodinated with a large excess of iodine monochloride and then radiolabeled by isotopic exchange with Na125I in a toluene-water two-phase system. The dependence of the radiolabehng yield on the reaction temperature and exchange time was examined. The radiolabeling yield of the compound was as high as 94% after heating for 2 hours at 130°C. © 2006 Akadémiai Kiadó.
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页码：599 / 603
页数：4
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