Development of an Experimental Model of Cardiac Failure Combined with Type I Diabetes Mellitus

被引：0
|
作者：
S. A. Afanasiev
D. S. Kondratyeva
S. V. Popov
机构：
[1] Siberian Division of the Russian Academy of Medical Sciences,Institute of Cardiology, Tomsk Research Center
来源：
Bulletin of Experimental Biology and Medicine | 2012年 / 153卷
关键词：
heart failure; type 1 diabetes mellitus; streptozotocin; coronary occlusion;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The doses and mode of streptozotocin injection for modeling heart failure combined with type 1 diabetes mellitus have been determined. Combined disease was induced in animals by injecting the selected streptozotocin dose (60 mg/kg intraperitoneally) at the stage of heart failure formation (2 weeks after coronary occlusion). This protocol of experiment led to development of hyperglycemia, body weight loss, and formation of myocardial cicatrix and hypertrophy corresponding to signs of heart failure paralleled by diabetes mellitus.
引用
收藏
页码：530 / 532
页数：2
相关论文
共 50 条
  • [41] Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis
    Rios-Arce, Naiomy D.
    Murugesh, Deepa K.
    Hum, Nicholas R.
    Sebastian, Aimy
    Jbeily, Elias H.
    Christiansen, Blaine A.
    Loots, Gabriela G.
    JBMR PLUS, 2022, 6 (05)
  • [42] Alkaline phosphatase variability and heart failure in type 2 diabetes mellitus: the hong kong diabetes study
    Tse, Gary
    Zhang, Qingpeng
    Adhikari, Govinda
    Cheung, Bernard
    Basit, Jawad
    Zhou, Jiandong
    Wong, Wing Tak
    Liu, Tong
    Chou, Oscar
    Chung, Cheuk To
    Bin Waleed, Khalid
    Lee, Sharen
    Wong, Ian
    HEART, 2023, 109 : A234 - A235
  • [43] Effects of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure
    Yusuf, S
    Ostergren, JB
    Gerstein, HC
    Pfeffer, MA
    Swedberg, K
    Granger, CB
    Olofsson, B
    Probstfield, J
    McMurray, JV
    CIRCULATION, 2005, 112 (01) : 48 - 53
  • [44] Evaluating the role of type 2 diabetes mellitus in rotator cuff tendinopathy: Development and analysis of a novel rat model
    Xu, Kuishuai
    Zhang, Liang
    Ren, Zhongkai
    Wang, Tianrui
    Zhang, Yingze
    Zhao, Xia
    Yu, Tengbo
    FRONTIERS IN ENDOCRINOLOGY, 2022, 13
  • [45] Induction of Type I Diabetes Mellitus in Beagle Dogs Using Alloxan and Streptozotocin
    Araujo, Joseph
    Paradis, Andrea
    Mendes, Jessica
    Petrik, Shawn
    de Rivera, Christina
    CURRENT PROTOCOLS, 2022, 2 (11):
  • [46] Hypoglycemic effect of hawthorn in type II diabetes mellitus rat model
    Aierken, Aili
    Buchholz, Tina
    Chen, Chen
    Zhang, Xiaoying
    Melzig, Matthias F.
    JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2017, 97 (13) : 4557 - 4561
  • [47] Cardiac remodeling and heart failure after a first anterior myocardial infarction in patients with diabetes mellitus
    Lamblin, Nicolas
    Fertin, Marie
    de Groote, Pascal
    Bauters, Christophe
    JOURNAL OF CARDIOVASCULAR MEDICINE, 2012, 13 (06) : 353 - 359
  • [48] Effects of canagliflozin on cardiac remodeling and hemodynamic parameters in patients with type 2 diabetes mellitus
    Kuo, Hsiao-Huai
    Lai, Yau-Huei
    Lin, Po-Lin
    Chen, Hsin-Hao
    Hung, Chung-Lieh
    Liu, Lawrence Yu-Min
    Yeh, Chih-Kuang
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [49] Cardiac perfusion, structure, and function in type 2 diabetes mellitus with and without diabetic complications
    Sorensen, Martin Heyn
    Bojer, Annemie Stege
    Broadbent, David Andrew
    Plein, Sven
    Madsen, Per Lav
    Gaede, Peter
    EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2020, 21 (08) : 887 - 895
  • [50] Effects of Vildagliptin on Ventricular Function in Patients With Type 2 Diabetes Mellitus and Heart Failure
    McMurray, John J. V.
    Ponikowski, Piotr
    Bolli, Geremia B.
    Lukashevich, Valentina
    Kozlovski, Plamen
    Kothny, Wolfgang
    Lewsey, James D.
    Krum, Henry
    JACC-HEART FAILURE, 2018, 6 (01) : 8 - 17
12345