Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing Hydrazinecarbothioamide or 1,2,4-Triazole Unit

被引：0

作者：

Lidia Lungu

Alexandru Ciocarlan

Alic Barba

Sergiu Shova

Serghei Pogrebnoi

Ionel Mangalagiu

Costel Moldoveanu

Nicoleta Vornicu

Michele D’Ambrosio

Maria V. Babak

Vladimir B. Arion

Aculina Aricu

机构：

[1] Institute of Chemistry,

[2] Laboratory “Chemistry of Natural and Biologically Active Compounds”,undefined

[3] ”P. Poni” Institute of Macromolecular Chemistry,undefined

[4] ”Al. I. Cuza” University of Iasi,undefined

[5] Faculty of Chemistry,undefined

[6] Metropolitan Center of Research T.A.B.O.R.,undefined

[7] University of Trento,undefined

[8] Laboratory of Bioorganic Chemistry,undefined

[9] National University of Singapore,undefined

[10] Department of Chemistry,undefined

[11] University of Vienna,undefined

[12] Institute of Inorganic Chemistry,undefined

来源：

Chemistry of Heterocyclic Compounds | 2019年 / 55卷

关键词：

homodrimane sesquiterpenoid; hydrazinecarbothioamide; 1,2,4-triazole; antibacterial activity; anticancer activity; antifungal activity; microwave irradiation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Synthesis of novel (+)-sclareolide-based homodrimane sesquiterpenoids bearing hydrazinecarbothioamide or N-substituted 1,2,4-triazole unit has been reported. These heterocyclic compounds demonstrate promising in vitro antifungal and antibacterial activities toward fungal species Aspergillus niger, Fusarium solani, Penicillium chrysogenum, Penicillium frequentans, and Alternaria alternata and bacteria strains Bacillus sp. and Pseudomonas aeruginosa at minimum inhibitory concentration level of μg/ml. In addition, two homodrimane sesquiterpenoids with hydrazinecarbothioamide fragment show cytotoxicity toward human ovarian carcinoma cells A2780 and A2780cis with half maximal inhibitory concentration values in range of 9–15 μM.

引用

页码：716 / 724

页数：8

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