A simple synthesis of 2-{2-[(arylmethylidene)amino]-indazol-3-yl}malonate esters

被引：0
|
作者：
Lyubov I. Kuznetsova
Alexey O. Chagarovskiy
Irina I. Levina
Victor B. Rybakov
Olga A. Ivanova
Igor V. Trushkov
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
[2] Oncology and Immunology,Dmitry Rogachev National Medical Research Center of Pediatric Hematology
[3] M. N. Emanuel Institute of Biochemical Physics,undefined
[4] Russian Academy of Sciences,undefined
[5] Lomonosov Moscow State University,undefined
来源：
Chemistry of Heterocyclic Compounds | 2020年 / 56卷
关键词：
aldehydes; alkenes; aziridines; indazoles; organic azides;
D O I：
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学科分类号：
摘要：
A method was developed for the synthesis of dimethyl {2-[(arylmethylidene)amino]-2H-indazol-3-yl}malonates on the basis of a Knoevenagel condensation between 2-azidobenzaldehyde and dimethyl malonate, followed by treatment of the obtained adduct with aromatic aldehydes in the presence of polymer-supported triphenylphosphine. It was shown that the interaction of the synthesized Schiff bases with Corey ylide provided a route for the synthesis of 2-(aziridin-1-yl)indazoles.
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页码：555 / 561
页数：6
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