Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells

被引:0
作者
Shara Khan
Richard Yan-Do
Eric Duong
Xichen Wu
Austin Bautista
Stephen Cheley
Patrick E. MacDonald
Matthias Braun
机构
[1] University of Alberta,Department of Pharmacology
[2] University of Alberta,Alberta Diabetes Institute, 6
来源
Diabetologia | 2014年 / 57卷
关键词
ATP; Calcium; Electrophysiology; Exocytosis; Insulin; Islets of Langerhans; Purinergic; Secretion;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:2535 / 2545
页数:10
相关论文
共 146 条
[1]  
Abbracchio MP(2006)International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy Pharmacol Rev 58 281-341
[2]  
Burnstock G(2006)Pharmacology of P2X channels Pflugers Arch 452 513-537
[3]  
Boeynaems J-M(1983)Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate Biochem J 210 297-305
[4]  
Gever JR(2011)Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content Interface Focus 1 143-152
[5]  
Cockayne DA(2007)Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells J Gen Physiol 129 221-231
[6]  
Dillon MP(1998)Cell surface measurements of ATP release from single pancreatic beta cells using a novel biosensor technique Pflugers Arch 437 31-35
[7]  
Hutton JC(2005)Selective nucleotide-release from dense-core granules in insulin-secreting cells J Cell Sci 118 4271-4282
[8]  
Penn EJ(2009)P2 purinergic signalling in the pancreatic beta-cell: control of insulin secretion and pharmacology Eur J Pharm Sci 37 67-75
[9]  
Peshavaria M(2012)Autocrine regulation of insulin secretion Diabetes Obes Metab 14 143-151
[10]  
Galvanovskis J(2001)P2 receptor agonists stimulate insulin release from human pancreatic islets Pancreas 22 69-71