Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice

[1] Verbrugge SJC(2007)Lung protective ventilatory strategies in acute lung injury and acute respiratory distress syndrome: from experimental findings to clinical application Clin Physiol Funct Imaging 27 67-90

[2] Lachmann B(1998)Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome N Engl J Med 338 347-54

[3] Kesecioglu J(2000)Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome N Engl J Med 342 1301-8

[4] Amato MB(2009)Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice Crit Care 13 R1-7

[5] Barbas CS(2012)Stress and strain within the lung Curr Opin Crit Care 18 42-22

[6] Medeiros DM(2013)Prolonged inspiratory time produces better gas exchange in patients undergoing laparoscopic surgery: a randomised trial: inspiratory time and gas exchange Acta Anaesthesiol Scand 57 613-16

[7] Magaldi RB(2013)The effects of prolonged inspiratory time during one-lung ventilation: a randomised controlled trial Anaesthesia 68 908-9

[8] Schettino GP(2002)Increasing inspiratory time exacerbates ventilator-induced lung injury during high-pressure/high-volume mechanical ventilation Crit Care Med 30 2295-20

[9] Lorenzi-Filho G(2011)Time to generate ventilator-induced lung injury among mammals with healthy lungs: a unifying hypothesis Intensive Care Med 37 1913-86

[10] Wolthuis EK(2011)Recurrent recruitment manoeuvres improve lung mechanics and minimize lung injury during mechanical ventilation of healthy mice PLoS One 6 e24527-608

[1] Verbrugge SJC(2007)Lung protective ventilatory strategies in acute lung injury and acute respiratory distress syndrome: from experimental findings to clinical application Clin Physiol Funct Imaging 27 67-90

[2] Lachmann B(1998)Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome N Engl J Med 338 347-54

[3] Kesecioglu J(2000)Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome N Engl J Med 342 1301-8

[4] Amato MB(2009)Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice Crit Care 13 R1-7

[5] Barbas CS(2012)Stress and strain within the lung Curr Opin Crit Care 18 42-22

[6] Medeiros DM(2013)Prolonged inspiratory time produces better gas exchange in patients undergoing laparoscopic surgery: a randomised trial: inspiratory time and gas exchange Acta Anaesthesiol Scand 57 613-16

[7] Magaldi RB(2013)The effects of prolonged inspiratory time during one-lung ventilation: a randomised controlled trial Anaesthesia 68 908-9

[8] Schettino GP(2002)Increasing inspiratory time exacerbates ventilator-induced lung injury during high-pressure/high-volume mechanical ventilation Crit Care Med 30 2295-20

[9] Lorenzi-Filho G(2011)Time to generate ventilator-induced lung injury among mammals with healthy lungs: a unifying hypothesis Intensive Care Med 37 1913-86

[10] Wolthuis EK(2011)Recurrent recruitment manoeuvres improve lung mechanics and minimize lung injury during mechanical ventilation of healthy mice PLoS One 6 e24527-608