Mesenchymal stem cell-derived exosomes improve motor function and attenuate neuropathology in a mouse model of Machado-Joseph disease

被引:0
作者
Hua-Jing You
Shu-Bin Fang
Teng-Teng Wu
Hongyu Zhang
Yu-Kun Feng
Xue-Jiao Li
Hui-Hua Yang
Ge Li
Xun-Hua Li
Chao Wu
Qing-Ling Fu
Zhong Pei
机构
[1] The First Affiliated Hospital,Department of Neurology
[2] Sun Yat-sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases,Otorhinolaryngology Hospital
[3] National Key Clinical Department and Key Discipline of Neurology,Department of Neurology
[4] The First Affiliated Hospital,Guangdong Provincial Key Laboratory of Laboratory Animals
[5] Sun Yat-sen University,undefined
[6] The Fifth Affiliated Hospital,undefined
[7] Sun Yat-sen University,undefined
[8] Guangdong Laboratory Animals Monitoring Institute,undefined
来源
Stem Cell Research & Therapy | / 11卷
关键词
Machado-Joseph disease; Mesenchymal stem cell-derived exosomes; Motor function; Neuropathology;
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[1]  
Martins S(2007)Asian origin for the worldwide-spread mutational event in Machado-Joseph disease Arch Neurol 64 1502-1508
[2]  
Calafell F(2012)Machado-Joseph disease/spinocerebellar ataxia type 3 Handb Clin Neurol 103 437-449
[3]  
Gaspar C(2013)Toward RNAi therapy for the polyglutamine disease Machado-Joseph disease Mol Ther 21 1898-1908
[4]  
Wong VC(2012)Toward understanding Machado-Joseph disease Prog Neurobiol 97 239-257
[5]  
Silveira I(2011)Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells J Biomed Sci 18 54-1918
[6]  
Nicholson GA(2013)Silencing mutant ATXN3 expression resolves molecular phenotypes in SCA3 transgenic mice Mol Ther 21 1909-9583
[7]  
Brunt ER(2013)ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy Nucleic Acids Res 41 9570-330
[8]  
Tranebjaerg L(2014)Mesenchymal stem cells ameliorate cerebellar pathology in a mouse model of spinocerebellar ataxia type 1 Cerebellum. 13 323-2151
[9]  
Stevanin G(2018)Repeated mesenchymal stromal cell treatment sustainably alleviates Machado-Joseph disease Mol Ther 26 2131-203
[10]  
Hsieh M(2011)Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model Mol Ther 19 196-11