Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)

被引：0

作者：

Dominique S. Michaud

Alina Vrieling

Li Jiao

Julie B. Mendelsohn

Emily Steplowski

Shannon M. Lynch

Jean Wactawski-Wende

Alan A. Arslan

H. Bas Bueno-de-Mesquita

Charles S. Fuchs

Myron Gross

Kathy Helzlsouer

Eric J. Jacobs

Andrea LaCroix

Gloria Petersen

Wei Zheng

Naomi Allen

Laufey Ammundadottir

Manuela M. Bergmann

Paolo Boffetta

Julie E. Buring

Federico Canzian

Stephen J. Chanock

Françoise Clavel-Chapelon

Sandra Clipp

Matthew S. Freiberg

J. Michael Gaziano

Edward L. Giovannucci

Susan Hankinson

Patricia Hartge

Robert N. Hoover

F. Allan Hubbell

David J. Hunter

Amy Hutchinson

Kevin Jacobs

Charles Kooperberg

Peter Kraft

Jonas Manjer

Carmen Navarro

Petra H. M. Peeters

Xiao-Ou Shu

Victoria Stevens

Gilles Thomas

Anne Tjønneland

Geoffrey S. Tobias

Dimitrios Trichopoulos

Rosario Tumino

Paolo Vineis

Jarmo Virtamo

Robert Wallace

机构：

[1] Imperial College London,Division of Epidemiology, Public Health and Primary Care

[2] Harvard School of Public Health,Department of Epidemiology

[3] National Institute for Public Health and the Environment (RIVM),Division of Cancer Epidemiology and Genetics, National Cancer Institute

[4] National Institutes of Health,Division of Cancer Control and Population Science

[5] Information Management Services,Department of Social and Preventive Medicine

[6] National Cancer Institute,Department of Obstetrics and Gynecology

[7] National Institutes of Health,Department of Environmental Medicine

[8] University at Buffalo,Department of Medical Oncology

[9] New York University School of Medicine,Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital

[10] New York University School of Medicine,Department of Laboratory Medicine/Pathology, School of Medicine

[11] NYU Cancer Institute,Prevention and Research Center

[12] Dana-Farber Cancer Institute,Department of Epidemiology

[13] Harvard Medical School,Division of Public Health Sciences

[14] University of Minnesota,Department of Health Sciences Research

[15] Mercy Medical Center,Department of Medicine and Vanderbilt

[16] American Cancer Society,Ingram Cancer Center

[17] Fred Hutchinson Cancer Research Center,Cancer Epidemiology Unit

[18] Mayo Clinic,Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services

[19] Vanderbilt University,Department of Epidemiology

[20] University of Oxford,Divisions of Preventive Medicine and Aging, Department of Medicine

[21] National Cancer Institute,Department of Ambulatory Care and Prevention

[22] National Institutes of Health,Center for Research on Health Care

[23] German Institute of Human Nutrition,Massachusetts Veterans Epidemiology Research and Information Center

[24] International Agency for Research on Cancer,Department of Nutrition

[25] The Tisch Cancer Institute,School of Medicine

[26] Mount Sinai School of Medicine,Department of Surgery

[27] Brigham and Women’s Hospital and Harvard Medical School,Department of Epidemiology

[28] Harvard Medical School,Julius Center for Health Sciences and Primary Care

[29] Division of Cancer Epidemiology,Department of Diet, Cancer and Health, Institute of Cancer Epidemiology

[30] German Cancer Research Center (DKFZ),Department of Hygiene and Epidemiology

[31] Inserm (Institut National de la Santé et de la Recherche Médicale) and Institut Gustave Roussy,Cancer Registry and Histopathology Department

[32] Johns Hopkins Bloomberg School of Public Health,Department of Chronic Disease Prevention

[33] George W. Comstock Center for Public Health Research and Prevention,Departments of Epidemiology and Internal Medicine

[34] University of Pittsburgh,undefined

[35] Veterans Affairs Boston Healthcare System,undefined

[36] Harvard School of Public Health,undefined

[37] University of California,undefined

[38] Core Genotyping Facility,undefined

[39] Advanced Technology Program,undefined

[40] SAIC-Frederick Inc.,undefined

[41] NCI-Frederick,undefined

[42] Bioinformed Consulting Services,undefined

[43] Malmö University Hospital,undefined

[44] Murcia Regional Health Council,undefined

[45] CIBER Epidemiología y Salud Pública (CIBERESP),undefined

[46] University Medical Center Utrecht,undefined

[47] Danish Cancer Society,undefined

[48] University of Athens Medical School,undefined

[49] “Civile-M.P.Arezzo” Hospital,undefined

[50] National Institute for Health and Welfare,undefined

来源：

Cancer Causes & Control | 2010年 / 21卷

关键词：

Alcohol; Pancreatic cancer; Pooled analysis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case–control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86–2.23, for 60 or more g/day vs. >0 to <5 g/day). A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02–4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63–2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake. Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out.

引用

页码：1213 / 1225

页数：12

共 325 条

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