Daytime Secretion of Salivary Cortisol and Alpha-Amylase in Preschool-Aged Children with Autism and Typically Developing Children

被引：0
作者：
Sharon A. Kidd
Blythe A. Corbett
Douglas A. Granger
W. Thomas Boyce
Thomas F. Anders
Ira B. Tager
机构：
[1] University of California,School of Public Health
[2] University of California at Davis Medical Center,M.I.N.D. Institute
[3] Pennsylvania State University,Department of Biobehavioral Health
[4] University of British Columbia,College for Interdisciplinary Studies and Faculty of Medicine
[5] National Fragile X Foundation,Center for Interdisciplinary Salivary Bioscience Research, School of Nursing and Bloomberg School of Public Health
[6] Vanderbilt Kennedy Center,undefined
[7] The Johns Hopkins University,undefined
来源：
Journal of Autism and Developmental Disorders | 2012年 / 42卷
关键词：
Autism; Children; Salivary cortisol; Salivary alpha-amylase; Diurnal; Variability;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We examined daytime salivary cortisol and salivary alpha-amylase (sAA) secretion levels and variability in preschool-aged children with autism (AUT) and typically developing children (TYP). Fifty-two subjects (26 AUT and 26 TYP) were enrolled. Salivary samples were obtained at waking, midday, and bedtime on two consecutive days at three phases (baseline, 3 months later, 6 months later). There were modest increases in waking cortisol and sAA levels in AUT relative to TYP, but the increases were not statistically significant. Important differences were observed in cortisol and sAA variability between AUT and TYP. There was also a graded response among AUT by functional status—cortisol and sAA secretion levels were higher when IQ was lower.
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页码：2648 / 2658
页数：10
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