Epidemiology, etiology, detection, and treatment of autoantibody-associated congenital heart block in neonatal lupus

被引：66
作者：
Friedman D.M. [1 ]
Rupel A. [1 ]
Buyon J.P. [1 ]
机构：
[1] New York University, School of Medicine, TCH-407, New York, NY 10016
来源：
Current Rheumatology Reports | 2007年 / 9卷 / 2期
基金：
美国国家卫生研究院;
关键词：
Complete Heart Block; Complete Atrioventricular Block; Neonatal Lupus; Conduction System Disease; Neonatal Lupus Erythematosus;
D O I：
10.1007/s11926-007-0003-4
中图分类号：
学科分类号：
摘要：
Neonatal lupus syndrome is a model of passively acquired autoimmunity in which the pregnant woman's serum contains specific antibodies to 52 or 60 kd SSA/Ro and/or 48 kd SSB/La, which cross the placenta and are associated with the development of congenital heart block in the fetus and/or a transient rash or various liver and blood cell abnormalities in the newborn. To date, congenital heart block is a permanent condition that entails significant morbidity and mortality, with nearly all affected infants requiring pacemakers and with an 80% cumulative probability of survival at 3 years of age. An intensive search is on for the specific etiopathophysiology and for new clinical tools to approach and treat this disease. Copyright © 2007 by Current Medicine Group LLC.
引用
收藏
页码：101 / 108
页数：7
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