Association of first trimester serum uric acid with preeclampsia: an observational cohort study with propensity score matching

被引:0
作者
Chaoyan Yue
Chunmei Ying
Xiaotian Li
机构
[1] Obstetrics and Gynecology Hospital of Fudan University,
来源
Hypertension Research | 2023年 / 46卷
关键词
Uric acid; Preeclampsia; Risk ratio; Cohort study;
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学科分类号
摘要
To elucidate whether uric acid changes in early pregnancy are associated with the development of preeclampsia and their association with preeclampsia-related adverse pregnancy outcomes. We conducted a retrospective cohort study of 4725 singleton pregnant women between January 2017 and July 2019 using propensity score matching. The primary outcome of the cohort was preeclampsia, and the secondary outcomes were preterm delivery, preterm preeclampsia and low birth weight infants. Multivariable predicted marginal proportions from logistic regression models were used to compute adjusted risk ratios. The quantitative-effect relationship between serum uric acid and preeclampsia development was observed by a dose‒response graph, and the effect of serum uric acid on the week of gestation at delivery was assessed using the Kaplan‒Meier method and the log-rank test. The risk of preeclampsia development increased with higher serum uric acid levels. After adjusting for confounders, the risk ratio for the development of preeclampsia with uric acid levels ≥240 µmol/l was 1.25 (95% CI: 0.96–1.65) compared with the group with uric acid levels <240 µmol/l. In the subgroup analysis of KM (Kaplan–Meier) curves, the gestational week at delivery was earlier when uric acid levels ≥240 µmol/l occurred at 8–12 weeks of gestation. Elevated serum uric acid levels before 20 weeks of gestation are associated with the development of preeclampsia, especially in the first 8–12 weeks of gestation, and the effect is attenuated with increasing gestational weeks, which suggests that elevated uric acid levels in early pregnancy may be a causative factor in preeclampsia.
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页码:377 / 385
页数:8
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  • [1] Medjedovic E(2019)Uric acid values along with Doppler sonography findings as a tool for preeclampsia screening Med Arch 73 408-11
  • [2] Suljevic A(2008)Uric acid as a pathogenic factor in preeclampsia Placenta 29 S67-72
  • [3] Iglica A(2018)Diagnostic performance of uric acid for prediction of preeclampsia Placenta. 62 79-94
  • [4] Rama A(2020)Uric acid and hypertension: an update with recommendations Am J Hypertens 33 583-83
  • [5] Mahmutbegovic E(2021)Uric acid and hypertension: prognostic role and guide for treatment J Clin Med 10 448-60
  • [6] Muftic A(2019)Uric acid and hypertension: a focused review and practical recommendations J Hypertens 37 878-8
  • [7] Bainbridge SA(2005)Uric acid and preeclampsia Semin Nephrol 25 56-40
  • [8] Roberts JM(2010)Could uric acid have a pathogenic role in pre-eclampsia? Nat Rev Nephrol 6 744-15
  • [9] Corominas A(2016)Serum uric acid may not be involved in the development of preeclampsia J Hum Hypertens 30 136-7
  • [10] Balconi S(2018)The role of uric acid in preeclampsia: is uric acid a causative factor or a sign of preeclampsia? Curr Hypertens Rep 20 80-22